What is Mesotherapy and how does it work?

Mesotherapy is a medical technique, it involves the micro-injection of a specially prepared mixture of vitamins, amino acids, and medications, placed into the Mesoderm (i.e. just millimetres under the skin) within a problematic area. It was initially used to treat such conditions as rheumatism, sports injuries, and for the improvement of blood circulation, and has now been used successfully by some practitioners for the treatment of cosmetic conditions, including skin rejuvenation, hair re-growth, localised fat reduction, and as a treatment for cellulite.

In France it is commonly practised by more than 15,000 practitioners and is taught in French medical schools. Mesotherapy is now also gaining widespread acceptance by cosmetic clinics in the UK and the USA.

The idea behind Mesotherapy is that you can get the active substances or ingredients, in small quantities, to the site requiring treatment by directly injecting them there. This is instead of relying on a tablet or intravenous injection where higher concentrations of a drug or other ingredient are required to be given in order to get adequate levels to the site requiring treatment.

The actual preparation injected during mesotherapy depends upon the problem being treated. In general, the substances used can include: local anesthetic, and products that may reduce inflammation, muscle relaxants, enzymes, vitamins, minerals, plant extracts, growth factors, hormones, and hormone blockers; to name but a few. Treatment is administered by multiple micro-injections using a very fine needle, which are either delivered individually by the practitioner’s hand or using a ‘meso-gun’ which fires the tiny needle into the skin and delivers a specified dose with more repetitions than can be achieved manually, hence making for a faster and some would argue more consistent treatment.

When used in the treatment of ageing skin Mesotherapy aims to replace minerals, vitamins and amino acids that are found in lower levels in skin as we age. It is also used to boost levels of Hyaluronic acid,  another important component of the skin that helps to maintain firmness and texture, levels of which decrease as skin ages. It is claimed that injecting more hyaluronic acid just below the surface of the skin helps to stimulate more collagen production, which, in turn, improves skin tone and helps to reduce fine lines and wrinkles.

What is No-Needle Mesotherapy and what can it treat?

Many people are not comfortable with the concept of multiple injections, so aesthetic device manufacturers have sought ways to offer no-needle alternatives.

No-needle options seek to achieve the same aim as injection Mesotherapy by encouraging the penetration of active ingredients applied topically to the skin, through the protective barrier layers of the skin’s surface, using mild electrical currents to assist the transportation of the substance between the skin cells. This pain-free option is therefore said to provide a viable Mesotherapy alternative for needle-phobias. It claims to be able to penetrate the skin up to 9 -10 cm and be able to introduce 90% of the active ingredients being administered.
No-needle Mesotherapy seeks to achieve the same aim as injection Mesotherapy and thus is targeted at the same treatment indications, such as skin re-hydration and toning as well as cellulite and fat reduction treatments.

No-needle Mesotherapy device is able to offer a minimum of twelve different treatments (some brands of machines can offer more) for the face and body using a variety of conjunctive ingredients and serums, including targeted fat, cellulite and stretch mark reduction, breast firming, treatment for stress related hair loss (alopecia), skin toning and tired eye treatment for dark circles, plus facials for preventative anti-ageing (under 30’s), rejuvenating with Hyaluronic acid (over 30’s), acne stop for mild to moderate acne and Mesolift for facial expression lines.

How do No-Needle Mesotherapy machines work?

No-needle Mesotherapy machines such as the Dermames Pro and the Aestech No-Needle Meso, uses a pulsed low frequency current (whose intensity is adjusted by the operator) to deliver a particular waveform which ionizes the molecules in the active ingredients used in the treatments and creates small channels in the skin for the ingredients to travel down. The head of the device is similarly charged to the ionized molecules and as it moves across the skin it repels the molecules deep into the skins layers. Ingredients contained in water soluble molecules permeate the skin’s natural lipid barrier and then cascade through the tissue beneath via minute channels created between the cells of up to 9 -10 cm, and is able to introduce 90% of the active ingredients being administered.

The treatments use a variety of substances derived from herb and vegetable extracts, as well as human growth hormones. Many of the ingredients exist naturally in the human body so the treatment is designed to provide a top-up to increase the body’s ability to burn fat or regenerate tissue.

What happens during a No-Needle Mesotherapy treatment?

Careful discussions regarding your reasons for wanting No-Needle Mesotherapy treatment are very important before you begin the treatment. You must also make sure that this treatment can deliver what you want and how you would like to look afterwards. It is also worth researching whether this is the right sort of treatment for you and how successful it has been on other patients. Your practitioner should be able to answer all these questions.

A medical history should also be taken to make sure that there are no reasons why you shouldn’t undertake treatment. You may be asked to sign a consent form which means that you have understood the potential benefits and risks associated with the procedure.

Photographs may also be taken by the practitioner for a “before and after” comparison at a later date.


Treatment sessions are carried out between once and twice a week and are likely to last about half an hour each.

Repeat Procedures

You should usually see changes within a couple of sessions, but 7 is the average number of suggested treatments. Monthly maintenance sessions are then suggested afterwards to maintain the results.

For fat reduction, often an eating plan, designed to reduce carbohydrates and advice on exercise shall be provided by a nutritionist for in between sessions.

How long will it take to recover from No-Needle Mesotherapy?

No recovery time is required and you can return to work or normal activities immediately after a treatment.

What are the risks and potential complications from No-Needle Mesotherapy treatment?

Treatments are said to feel like a ‘pins and needles’ sensation, but are generally described as comfortable. There are said to be virtually no risks or side effects for healthy candidates.
However, there is the possibility of allergic reaction to one or more of the ingredients within the topically applied serums used which would become apparent immediately on application by the appearance of redness. Any likely candidate with a history of allergies is therefore advised to take a patch test before treatment.

Who should not have No-Needle Mesotherapy treatment?

As long as you are generally healthy and don’t have any skin diseases or infections in the area treated, there are few medical reasons why patients should not undergo this treatment.

Although, due to the electrical output of the devices used, treatment is not suitable for pregnant women or those people with epilepsy, pacemakers or any serious psychological or medical condition.

Who can perform No-Needle Mesotherapy?

Suitably trained non-medical therapists can perform No-Needle Mesotherapy treatments.
This treatment is most commonly found in beauty salons or non-surgical clinics.

What is the average cost of No-Needle Mesotherapy?

Private costs for No-needle Nesotherapy depend on the size of the area(s) being treated and the indication for treatment. For example, private costs for a programmable of No-needle Mesotherapy sessions will cost from £80 to £400, with an average of approximately £250.

Summary for No-Needle Mesotherapy

No-Needle Mesotherapy seeks to achieve the same aim as injection Mesotherapy and thus is targeted at the same treatment indications, such as skin re-hydration and toning as well as cellulite and fat reduction treatments.

It uses a pulsed low frequency electric current to deliver active ingredients into the skin.

Whilst Mesotherapy gives visible  results after just 4-sessions, the medical jury is still very much out on whether or not needle Mesotherapy produces long term, lasting results for the variety of areas that it claims to treat. Many practitioners believe that the effects are from the needling itself and not the introduction of any substances however what is undisputed is that both Needle and No-Needle Mesotherapy have a high client satisfaction rating and offer one of the highest repeat sale value of all clinical and spa treatments.

Unfortunately very little clinical data exists for such No-Needle Mesotherapy devices however Aestech Medical Supplies are currently undergoing two independent clinical trials on their Mesotherapy machines and have completed a 3-year case study through independant dermatology clinics.

One retrospective review of 38 patients, (30 female and 8 male), from Edinburgh who completed a course of seven treatments for targeted fat reduction on the abdomen and were also given eating plans to reduce carbohydrates and advised to exercise, showed an average female weight loss of 6.5 lbs, and an average loss of 4.7 cm on the upper abdomen, 6.12 cm on the lower and 7.23 cm on the midriff. Results for male patients were comparable. Results varied between individuals and the devices used, but The Aestech Dermames Pro showed the greatest results.


To view the Aestech Dermames Pro, click here